Also known as the EIA/TIA-449, the RS-449 is short for Recommended Standardard-449 and is a data standard that specifies the functional and mechanical characteristics of the interconnection between DTE and complying EIA electronic standards RS-422 and RS-423. The RS-449 standard is commonly found in data network communication equipment. Below is a layout of the 37-pin configuration for the RS-449, starting with pin 1 that is generally located at the top left of the connector.
| Pin | Signal | Source |
| 1 | Shield | Common |
| 2 | Signal rate indicator | DTE |
| 3 | Unassigned | Unassigned |
| 4 | Send data | DTE |
| 5 | Send timing | DCE |
| 6 | Received data | DCE |
| 7 | Request to send | DTE |
| 8 | Receive timing | DCE |
| 9 | Clear to send | DCE |
| 10 | Local loopback | DTE |
| 11 | Data mode | DCE |
| 12 | Terminal ready | DTE |
| 13 | Receiver ready | DCE |
| 14 | Remote loopback | DTE |
| 15 | Incoming call | DCE |
| 16 | Select frequency | DTE |
| 17 | Terminal timing | DTE |
| 18 | Test mode | DCE |
| 19 | Signal ground | Common |
| 20 | Receive common | Common |
| 21 | Unassigned | Unassigned |
| 22 | Send data | Return |
| 23 | Send timing | Return |
| 24 | Receive data | Return |
| 25 | Request to send | Return |
| 26 | Receive timing | Return |
| 27 | Clear to send | Return |
| 28 | Terminal in service | DTE |
| 29 | Data mode | Return |
| 30 | Terminal ready | Return |
| 31 | Receiver ready | Return |
| 32 | Select standby | DTE |
| 33 | Signal quality | DCE |
| 34 | New signal | DTE |
| 35 | Terminal timing | Return |
| 36 | Standby indicator | DCE |
| 37 | Send common | Common |
Also see: DTE, RS-232, RS-422, RS-423, RS-485 | |
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